A. C. Polarography of Thiamine Hydrochloride in Weakly Acidic Buffer Solutions

A Toxicity Study of Thiamine Hydrochloride.

Observations on the mechanism of thiamine hydrochloride absorption in man.

1. The intestinal absorption of [35S]thiamine hydrochloride was investigated in healthy subjects, malnourished alcoholics and a patient with resection of the jejunum and ileum. Serum and urinary radioactivity was studied after administration of 10 pCi of [35S]thiamine hydrochloride in 1-50 mg of non-radioactive thiamine hydrochloride. 2. Results suggest that intestinal absorption of thiamine hy...

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

BACKGROUND High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects. METHODS This was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated...

Spectrophotometric Determination of Acidity Constants of Thiamine in Water, Water-Triton X-100 Micellar Media Solutions

In this work the acidity constants of Thiamine in water and water-Triton X-100 micelle media solutions, at 25 °C, have been determined spectrophotometrically. To evaluate the pH- absorbance data, a resolution based on the combination of soft-and hard-modeling is applied. The acidity constants of all related equilibria are estimated using the whole spectral fitting of the collected data to a...

Thiamine hydrochloride (Vit-B1): An optimized green alternative for the synthesis of polyhydroquinoline derivatives

Thiamine hydrochloride (Vitamin-B1) has been utilized as an effective biodegradable catalyst for the one pot synthesis of polyhydroquinoline derivatives via four component reaction of dimedone, aldehyde, ethylacetoacetate and ammonium acetate in ethanol under mild conditions. The method presented here offers several advantages over reported procedures in terms of environmentally benign catalyti...